Drug Induced of Cutaneous Pseudo- Lymphomas

Lymphoproliferative infiltrates could be seen in several skin diseases but they are very characteristic of cutaneous pseudolymphoma, which can mimic both clinically and histopathologically cutaneous malignant pseudolymphoma. A big problem for the clinicians is the differential diagnosis between cutaneous pseudolymphoma and malignant cutaneous lymphomas, as well as possibility for transformation of cutaneous pseudolymphoma into malignant lymphomas. Wide spectrum of medicaments could cause appearance of cutaneous pseudolymphoma. Some of them are: anticonvulsants, ACE inhibitors, neuroleptics and others. Many of them are responsible for a development of erythrodemia, simulating Sezary syndrome with peripheral blood changes.